Magnesium Ascorbate being a natural neutral salt has significantly higher gastrointestinal tolerance and hence is more safe and effective in Magnesium therapy. Knowing the widespread requirements the body has for magnesium, magnesium is being looked to more and more as adjunct to several medical regimens. The more magnesium is investigated, the more far reaching are its apparent benefits.

This organically bound form of magnesium is recognized as the natural and more bio-available delivery system for the vital anti-stress mineral.

Structure

Requirements
The Food and Nutrition Board of the Institute of Medicine of the United States National Academy of Sciences has recommended the following Adequate Intake (AI) and Recommended Dietary Allowance (RDA) values for magnesium

Age (Year)
Infants

AI (milligrams/day)

0 – 6 months

30

7 – 12 months

75

Children

RDA (milligrams/day)

1 – 3 years

80

4 – 8 years

130

Boys

9 – 13 years

240

4 – 18 years

410

Girls

9 – 13 years

240

4 – 18 years

360

Men

19 – 30 years

400

31 – 70 + years

420

Women

19 – 30 years

310

31 – 70 + years

320

Pregnancy

14 – 18 years

400

19 – 30 years

350

31 – 50 years

380

Lactation

14 – 18 years

360

19 – 30 years

310

31 – 50 years

320

Nutritional significance of Magnesium in cardiovascular treatment

Magnesium’s importance to the health of a large number of biological systems is receiving ever-increasing support. Magnesium has an essential part in hundreds of biochemical roles, and depending upon the biological systems in the body that is involved, it may perform its function via different mechanisms.

Magnesium’s place in the area of platelet aggregation appears to be crucial to the control or palliation of a number of important health problems. The hyperactivity of platelets that results in their aggregation and the subsequent release of potent vasoconstrictors may be at the base of problems, such as migraine headaches and vascular diseases associated with diabetes, strokes and various cardiovascular diseases.

Recent research indicates magnesium deficiency may be a factor in the development of atherosclerosis and coronary artery disease- the major cause of heart attacks. Several clinical studies indicate that maintenance of adequate red blood cell magnesium levels may be key in fighting these health problems.

Role of Ascorbic acid in cardiovascular therapy

In the early 1990s, several large population studies showed a reduction in cardiovascular disorder in those who consumed vitamin C (Ascorbic acid). A study, which evaluated 11,348 participants over a ten-year period of time, showed that high vitamin C intake extended average life span and reduced mortality due to cardiovascular disease by 42%. This was again confirmed by a study involving 11,178 participants who took vitamin C and vitamin E supplements.

Several studies suggest different mechanism of action by which ascorbic acid protects against cardiovascular disease.

  1. Atherosclerosis is a natural protective mechanism against the arterial deteriorating effects by a vitamin C deficiency. Thus vitamin C deficiency leads to atherosclerosis which in turn causes cardiovascular disease.

  2. Vitamin C enables the arterial system to expand and contract with youthful elasticity.

  3. Co-administration of nitrate drugs with vitamin C to coronary artery disease patients prolongs the vasodilating effects of the nitrate drugs and the energy producing capacity of the cells is maintained. Otherwise, nitrate drugs alone cause progressive weakening of the heart muscle’s ability to produce energy and also the vascular system stops responding to the dilating effects of the drug. Vitamin C thus potentially helps to prevent the development of nitrate tolerance.

  4. An especially damaging effect of nitrate drugs is that they cause a decrease in the intracellular product of cGMP. This energy substrate is required to maintain cellular energy levels. Vitamin C has been shown to protect against nitrate-induced depletion of cGMP. The use of vitamin C during pre-treatment with nitrate drugs increased the availability of nitric oxide, an important precursor to cGMP.

Thus published research findings suggest that ascorbic acid may reduce mortality in coronary artery disease patients, increase life span and possibly eliminate the effects of nitrate tolerance in those taking nitrate drugs.

Magnesium Ascorbate, which provides both Magnesium and Ascorbic acid (Vitamin C) appears to be unique and promising product, in that both the components have the potential to reduce the risk of cardiovascular disease.

Other nutritionally important roles of Magnesium and
L- Ascorbic acid

Magnesium is the fourth most abundant mineral in the body. It is essential to build the bones and teeth and numerous metabolic functions.

Magnesium is also an ingredient in some antacids and laxatives and is used to prevent premature birth and treat certain types of convulsions and rapid heartbeats (tachycardia). Magnesium works with calcium and phosphorous to build strong bones and teeth.

It also plays important roles in:

  • Normal metabolism

  • Proper nerve and muscle function

  • Stimulating calcium function

  • Preventing dental cavities

  • Promoting immunity and

  • Boosting the actions of potassium and some of B-vitamins

  • It may also aid in the treatment of asthma, cardiac arrhythmia, high blood pressure, fibromyalgia and diabetes.

In addition to its use for the treatment of hypomagnesemia, magnesium is used for the treatment of certain cardiac arrhythmia’s, in particular torsasde de points and eclampsia. Magnesium may also have value for the prevention of osteoporosis and for the management of migraine headaches in some. There is preliminary evidence that magnesium may help some with premenstrual syndrome, type 2 diabetes mellitus and hypertension.

Ascorbic acid is involved in modulating iron absorption, transport and storage. It aids in the intestinal absorption of iron by reducing ferric iron to ferrous iron and may stimulate ferritin synthesis to promote iron storage in cells. It is involved in the biosynthesis of corticosteroids, aldosterone, the conversion of cholesterol to bile acids and functions as a reducing agent for mixed-function oxidases.

For all of this, ascorbic acid is best known for its antioxidant properties and its possible role in the prevention of certain chronic degenerative disorders, such as coronary heart disease and cancer. In fact, ascorbic acid may be the most important water-soluble antioxidant in the body.

Ascorbic acid has antioxidant activity. It may also have antiatherogenic, anticarcinogenic, antihypertensive, antiviral, antihistaminic, immunomodulatory, opthalmoprotective and airway-protective actions. It may aid in the detoxification of some heavy metals, such as lead and other toxic chemicals.

Ascorbic acid or, more specifically, ascorbate is an excellent reducing agent, and it acts as cofactor in various biochemical reactions to reduce the transition metals, iron and copper. It can be oxidized by most reactive oxygen and nitrogen species thought to play roles in tissue injury associated with various diseases. By virtue of this scavenging activity, ascorbate inhibits lipid peroxidation, oxidative DNA damage and oxidative protein damage.

The antioxidant activity of ascorbate is well established and that activity may be helpful in the prevention of some cancers and cardiovascular diseases. It may also be helpful in protecting against some of the lipid oxidation caused by smoking.

Ascorbic acid may also be helpful as immune stimulator and modulator in some circumstances. It may help prevent cataract.

 


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