Magnesium fumarate is a "nutrient dense" supplementary form of magnesium and an energy rich substrate -fumarate and has a positive effect in stressful conditions. Magnesium as quantitative element is an essential part of the animal nutrition, Fumarate is one of the key intermediate of the Krebs cycle, which contributes to efficient energy production in human physiological systems. Magnesium fumarate helps to increase body magnesium levels and thus enhance the benefits of magnesium to many areas that are concerned with energy and muscular performance. ATP is produced in the Krebs Cycle of which fumarate is one of the key intermediates. Carbohydrate, lipids and proteins cannot produce the sources of muscle contraction energy i.e., ATP, without the presence of magnesium. Thus magnesium has been intimately linked to all aspects of body’s production of energy. As Magnesium Fumarate, both the key ingredients for energy production are concomitantly supplied to the system ensuring efficient energy production.
Structure

Requirements

The Food and Nutrition Board of the Institute of Medicine of the United States National Academy of Sciences has recommended the following Adequate Intake (AI) and Recommended Dietary Allowance (RDA) values for magnesium:

Age (Year)

AI (milligrams/day)

Infants

0 – 6 months

30

7 – 12 months

75

Children

RDA (milligrams/day)

1 – 3 years

80

4 – 8 years

130

Boys

9 – 13 years

240

4 – 18 years

410

Girls

9 – 13 years

240

4 – 18 years

360

Men

19 – 30 years

400

31 – 70 + years

420

Women

19 – 30 years

310

31 – 70 + years

320

Pregnancy

14 – 18 years

400

19 – 30 years

350

31 – 50 years

380

Lactation

14 – 18 years

360

19 – 30 years

310

31 – 50 years

320

Significance of Magnesium in Human Nutrition
Magnesium is a mineral found almost everywhere in nature. Magnesium is required for energy production; the more a person has to work the more magnesium he or she requires, since this mineral is involved in more than 300 metabolic processes in the body.

Magnesium is an essential Co-factor in many enzyme reactions in human energy and protein metabolism, its involvement as an intracellular catalyst in vital processes extends from glycolysis to the tricarboxylic acid cycle and to DNA synthesis.

Magnesium supplementation may provide a new therapeutic approach to reducing vascular disease and in diabetic conditions.

From the great variety of magnesium’s biological functions and their importance for the human body, it is vital to have an adequate supply of this element and that a deficiency will inevitably have serious consequences.

Deficiency symptoms of Magnesium

Symptoms and signs of magnesium deficiency includes anorexia, nausea and vomiting, diarrhea, generalized muscle spasticity, paresthesias, confusion, tremor, focal and generalized seizures, confusion, loss of coordination, cardiac arrhythmias, laboratory abnormalities, such as hypokalemia and coronary and cerebral vasospasms. Magnesium deficiency may be found in diabetes mellitus, malabsorption syndromes, alcoholism and hyperthyroidism, among other disorders.

Due to increasingly common sub optimal magnesium in many countries, which become particularly evident in situation of heightened need (pregnancy, emotional and physical stress), oral magnesium supplementation has gained a lot of importance.

Fumaric acid in the treatment of psoriasis
As the citric acid cycle is the center for energy production within the cell, fumaric acid must be present in every cell of the body, being a by-product of the cycle. It is therefore not something that is foreign to the body.

Although fumaric acid is not a foreign substance, it is metabolically very active.

A lack of fumaric acid leads to the accumulation of half-products. These products, it is believed, are responsible for the skin lesion in-patients with Psoriasis. In administering the lacking fumaric acid slowly to the body, the psoriasis can come to a halt. The administration of the acid should be slow, as it is a metabolically very active substance. However the administration of too little fumaric acid will result in a therapeutic failure, whereas too much can lead to heat waves and a drop in blood sugar. This is a very rare occurrence.

Psoriasis is regarded as a disease resulting from a metabolic error, possibly in the formation of  fumaric acid in the skin. Fumaric acid is the trans-isomer of Malic acid. It is an important compound biochemically since it enters into the citric acid cycle. Fumarate is a by-product at certain stages in the arginine –urea cycle, and in purine biosynthesis.

In healthy individuals, fumaric acid is formed in the skin when it is exposed to sunlight (from the ultra-violet part of the spectrum). Apparently, patients suffering from Psoriasis have a biochemical defect in which they cannot produce enough fumaric acid and need prolonged exposure to the sun to produce it. This is one reason why patients frequently notice an improvement of their skin condition in the summer months and also explains, in part, the efficacy of PUVA treatment.

Fumaric acid has acidulant, antidermatitic, antihepatocarcinogenic, antioxidant, antipsoriatic and antitumor properties.

Both the constituents of Magnesium Fumarate has very important roles to play in human nutrition. Being naturally available in the body, both magnesium and fumaric acid are metabolically very active and their deficiency is bound to have serious consequences. Hence their supplementation as a single entity, assures a concomitant and adequate supply of both vital ingredients.

 


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