Molybdenum methionate is a stable bioavailable organically bound complex of molybdenum with the essential amino acid methionine. Molybdenum is found in several tissues of the human body and is required for the activity of some enzymes that are involved in catabolism, including the catabolism of purines and sulphur amino acids. Methionine is "sulfur" containing essential amino acid, which has potential free radical scavenging activity, and also involved in a wide range of biochemical reactions. Thus Molybdenum methionate as a delivery form of molybdenum not only facilitates the supplementation of molybdenum but also supplies methionine and as well ensures its proper utilization in the body.
Structure

Requirements

The Food and Nutrition Board of the U.S. National Academy of Sciences has recommended the following "Estimated Safe and Adequate Daily Dietary Intake" (ESSADI) values for molybdenum

Age (Years) ESSADI (micrograms / day)
Infants
0 – 0.5
0.5 – 1
15 – 30
20 – 40
Children
1 – 3
4 – 6
7 – 10
11 – 18
25 – 50
30 – 75
50 – 150
75 – 250
Adults
19 + years

75 – 250

The US RDA for Molybdenum is 75 m g/day

Nutritional role of Molybdenum in human body

Molybdenum is an essential trace mineral in animal and human nutrition. It is found in several tissues of the human body and is required for the activity of some enzymes that are involved catabolism, including the catabolism of purines and sulfur amino acids.

It is also needed to build strong tooth enamel and it may help prevent dental decay.

Molybdenum prevents and treats molybdenum deficiency. Molybdenum has putative anti-carcinogenic activity. As a component of various enzyme systems, molybdenum plays essential roles in the metabolism of carbohydrates, fats, proteins, amino acids that contain sulfur, iron, and genetic material.

ffects of Molybdenum Deficiency

Molybdenum Deficiency is very rare, occurring mostly as a consequence of other serious disorders or a build up of copper and / or sulfate. Symptoms include breathing problems and neurological disorders.

The deleterious effects of molybdenum deficiency were primarily due to the accumulation of sulfite coming from the catabolism of L-cysteine. Sulfite is toxic to the nervous system and molybdenum is necessary for its metabolism to a nontoxic form. Both tungsten and copper are molybdenum antagonists. Molybdenum deficiency in animals, results in retarded weight gains, decreased food consumption, impaired reproduction and shortened life expectancy. High intake of molybdenum is antagonistic to copper and can produce a condition in animals known as molybdenosis.

Significance of Methionine in human body

L-methionine is protein amino acid. It is classified as an essential amino acid for human and therefore must be supplied in the diet.

L-methionine is also glycogenic amino acid and may participate in the formation of D-glucose and glycogen.

L-methionine may protect against the toxic effects of hepatotoxins, such as acetaminophen. Antioxidant activity of L-methionine and metabolites of L-methionine appear to account for its possible anti-hepatotoxic activity. Recent research suggests that methionine itself has free radical scavenging activity by virtue of its sulfur, as well as its chelating ability

In addition to its role as a precursor in protein synthesis, L-methionine participates in a wide range of biochemical reactions, including the production of S-adenosylmethionine (SAM or SAMe), L-cysteine, glutathione, taurine and sulfate. SAM itself, as a methyl donor, is involved in the synthesis of creatine, epinephrine, melatonin and the polyamines, spermine and spermidine, among several other substances.

Methionine is also involved in breaking down fats. Since women who eat a high fat diet tend to have an increase in circulating estrogens, some experts recommend it to help eliminate excess estrogen.

        

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