Zinc Ascorbate is a natural gentle immune booster and represents "Optimal Nutritional" supplement of the vital micromineral Zinc. Zinc plays important roles in immunity, and various metabolic processes. Ascorbic acid’s immunomodulatory properties and use as immune stimulator is accentuated when used as Zinc Ascorbate due to the ready availability Zinc.

Structure

Requirements
The Food and Nutrition Board of the Nutrition Board of the National Academy of Sciences has recommended the following Recommended Dietary Allowances (RDA) for zinc
Age (years) RDA (milligrams/day)
0 – 1 05
1 – 10 10
Males 11 – 51+ 15
Females 11 – 51+ 12
Pregnant 15
Lactating
First 6 months 19
Second 6 months 6

Nutritional significance of Zinc – a multifaceted trace mineral

Zinc is a component of the enzymes involved in most major metabolic pathways, and as such, is essential for human life. Large amounts of Zinc are deposited in bone and muscle, but unfortunately, these stores of Zinc are not easily available to the rest of the body. The human body’s pool of accessible Zinc is small and susceptible to rapid turnover----- deficiency signs appear quickly. Zinc deficiency has an immediate effect on cell growth and repair since it participates in over 80 enzymes and harmone functions, including many involved in gene expression.

Zinc is essential for development and proper functioning of the reproductive organs and normal functioning of the prostate gland.

Zinc plays a central role in cell-mediated immune function and also is supposed to play significant roles in HIV patients.

Recent research indicates that it may help fight the common cold and other infection; it may also be useful in treating fibromyalgia, osteoporosis, and rheumatoid arthritis.

Zinc is essential in human and animal nutrition with a wide range of biological roles. Zinc plays catalytic, structural and regulatory roles in more than 200 zinc metalloenzymes that have been identified in biological systems. These enzymes are involved in nucleic acid and protein metabolism and the production of energy among other things. Zinc plays structural roles in so called Zinc fingers. Zinc fingers are exploited by transcription factors for interacting with DNA and regulating the activity of genes. Another structural role of zinc is in the maintenance of the integrity of biological membranes resulting in their protection against oxidative injury, among other things.

Zinc is involved in several metabolic processes and body functions, which include the following:

Normal growth and development: Zinc plays important roles in bone growth and mineralization and the development of reproductive organs.

Maintaining healthy skin and bones: Zinc deficiency is linked to various skin disorder, including eczema, acne, and excessive flaking similar to what occurs in psoriasis. Hair becomes dull and lifeless looking.

Metabolic processes: Zinc is a component of various enzyme systems, and it is essential for the synthesis and metabolism of proteins and genetic material.

Healing and immune function: Zinc promotes the healing of burns and common infections.

Taste and smell: Zinc’s role in these senses enables a person to distinguish the taste of different foods.

Physiologically, zinc is vital for growth and developments, sexual maturation and reproduction, dark vision adaptation, olfactory and gustatory activity, insulin storage and release and for a variety of host immune defenses, among other things.

Zinc may have immunomodulatory activity. It may also have antioxidant activity. Zinc has putative antiviral, fertility- enhancing and retinoprotective activities.

Zinc is essential for proper formation and maturation of spermatozoa. There is some evidence that zinc can promote and accelerate wound healing in some circumstances. Zinc is also very important to the newborn when breast milk may be its only sources of Zinc.

Manifestations of Zinc Deficiency

Zinc deficiency may be classified as severe, moderate or mild.

a) Severe Zinc Deficiency Manifestations:Bullous pustular dermatitis, alopecia, diarrhea, emotional disorder, weight loss, inter-current infections due to cell-mediated immunedysfunction, hypogonadism in males, neurosensory disorders, and problems with healing of ulcers. This condition can be fatal.

b) Moderate Zinc Deficiency Manifestations:Growth retardation and male hypogondism in adolescence, rough skin, poor appetite, mental lethargy, delayed wound healing, cell-mediated immune dysfunction, and abnormal neurosensory changes.

c) Mild Zinc Deficiency Manifestations:Decreased serum testosterone levels and oligospermia in males, decreased lean body mass, hyperammonemia, neurosensory changes, anergy, decreased serum thymulin activity, and decreased IL-2activity.

Role of Ascorbic acid in human nutrition

Ascorbic acid is involved in modulating iron absorption, transport and storage. It aids in the intestinal absorption of iron by reducing ferric iron to ferrous iron and may stimulate ferritin synthesis to promote iron storage in cells. It is involved in the biosynthesis of corticosteroids, aldosterone, the conversion of cholesterol to bile acids and functions as a reducing agent for mixed-function oxidases.

For all of this, ascorbic acid is best known for its antioxidant properties and its possible role in the prevention of certain chronic degenerative disorders, such as coronary heart disease and cancer. In fact, ascorbic acid may be the most important water-soluble antioxidant in the body.

Ascorbic acid has antioxidant activity. It may also have antiatherogenic, anticarcinogenic, antihypertensive, antiviral, antihistaminic, immunomodulatory, opthalmoprotective and airway-protective actions. It may aid in the detoxification of some heavy metals, such as lead and other toxic chemicals.

Ascorbic acid or, more specifically, ascorbate is an excellent reducing agent, and it acts as cofactor in various biochemical reactions to reduce the transition metals, iron and copper. It can be oxidized by most reactive oxygen and nitrogen species thought to play roles in tissue injury associated with various diseases. By virtue of this scavenging activity, ascorbate inhibits lipid peroxidation, oxidative DNA damage and oxidative protein damage.

The antioxidant activity of Ascorbates is so well established and that activity may be helpful in the prevention of some cancers and cardiovascular diseases. It may also be helpful in protecting against some of the lipid oxidation caused by smoking.

It may also be helpful as immune stimulator and modulator in some circumstances. It may help prevent cataract.

Recently it was demonstrated that vitamin C can inhibit growth of Heliobacter pylori and may thus be protective against some ulcers and gastric carcinomas.

It may be of benefit in some burn victims and may be helpful, generally, in promoting wound healing and gum health. It has also shown benefit in some with asthma. Ascorbic acid supplementation has a positive impact in reduction of cardiovascular diseases.

Supplemental zinc may be helpful in some of the foregoing, in some conditions of immune impairment, in some complications of pregnancy, in the prevention of some cases of fetal neural tube defects, diarrhea, oligospermia, delayed wound healing and some cognitive disorders. It may also help against some inflammatory disorders.

Zinc Ascorbate is better absorbed than the inorganic Zinc salts. Also being neutral salts it exhibits better to tolerance and also better utilization. It also has greater tissue retention and is gentler on the system.

 


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